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KMID : 0363020120420060248
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Journal of Korean Academy of Periodontology
2012 Volume.42 No. 6 p.248 ~ p.255
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Surface characteristics and osteoblastic cell response of alkali-and heat-treated titanium-8tantalum-3niobium alloy
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Lee Bo-Ah
Kang Choong-Hee
Vang Mong-Sook
Jung Young-Suk
Piao Xing Hui
Kim Ok-Su
Chung Hyun-Ju
Kim Young-Joon
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Abstract
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Purpose: The aim of the present study was to evaluate the biological response of alkali- and heat-treated titanium-8tantalum-3niobium surfaces by cell proliferation and alkaline phosphatase (ALP) activity analysis.
Methods: Commercial pure titanium (group cp-Ti) and alkali- and heat-treated titanium-8tantalum-3niobium (group AHT) disks were prepared. The surface properties were evaluated using scanning electron microscopy, energy dispersed spectroscopy and X-ray photoelectron spectroscopy (XPS). The surface roughness was evaluated by atomic force microscopy and a profilometer. The contact angle and surface energy were also analyzed. The biological response of fetal rat calvarial cells on group AHT was assessed by cell proliferation and ALP activity.
Results: Group AHT showed a flake-like morphology microprofile and dense structure. XPS analysis of group AHT showed an increased amount of oxygen in the basic hydroxyl residue of titanium hydroxide groups compared with group cp-Ti. The surface roughness (Ra) measured by a profilometer showed no significant difference (P>0.05). Group AHT showed a lower contact angle and higher surface energy than group cp-Ti. Cell proliferation on group AHT surfaces was significantly higher than on group cp-Ti surfaces (P<0.05). In comparison to group cp-Ti, group AHT enhanced ALP activity (P<0.05).
Conclusions: These results suggest that group AHT stimulates osteoblast differentiation.
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KEYWORD
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Alkaline phosphatase, Cell adhesion, Cell proliferation, Surface properties, Titanium alloy
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